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Updated: Aug 4, 2025

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
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Clinical trials using dental stem cells: 2022 update.

Wen-Peng Song1, Lu-Yuan Jin2, Meng-Di Zhu2

  • 1Department of Stomatology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.

World Journal of Stem Cells
|April 3, 2023
PubMed
Summary

Dental stem cells (DSCs) show promise for treating various conditions, with clinical trials demonstrating satisfactory effects and no reported adverse events, highlighting their safety and therapeutic potential.

Keywords:
Adult stem cellsDental pulpDental stem cellsTissue regeneration

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Area of Science:

  • Regenerative Medicine
  • Dental Research
  • Stem Cell Biology

Background:

  • Dental stem cells (DSCs) are obtainable from multiple oral tissues.
  • DSCs possess self-renewal, multidirectional differentiation, and immunomodulation capabilities.
  • These properties indicate significant potential for clinical applications.

Purpose of the Study:

  • To review the characteristics of DSCs.
  • To summarize clinical trials utilizing DSC-based therapies.
  • To assess the safety and discuss limitations and future perspectives of DSC-based therapies.

Main Methods:

  • Literature review of clinical articles and trials involving DSCs.
  • Analysis of reported outcomes and adverse events in DSC-based therapies.
  • Discussion of current challenges and future research directions.

Main Results:

  • DSCs have been successfully applied in treating pulpitis, periapical lesions, periodontitis, cleft lip and palate, and acute ischemic stroke.
  • Most clinical trials reported satisfactory therapeutic effects.
  • No adverse events were documented in the reviewed studies, suggesting safety.

Conclusions:

  • DSC-based therapies demonstrate considerable clinical efficacy and safety.
  • Further research is needed to address limitations, including harvesting from inflamed tissues and developing expansion-free strategies.
  • Exploring DSC-conditioned medium and extracellular vesicles offers promising avenues for future applications.