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Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

91.8K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
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Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

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Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
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Related Experiment Video

Updated: Aug 4, 2025

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
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Molecular methods for colorectal cancer screening: Progress with next-generation sequencing evolution.

Salma Abbes1, Simone Baldi2, Hayet Sellami3

  • 1Laboratory of Parasitic and Fungal Molecular Biology, University of Sfax, Sfax 3029, Tunisia.

World Journal of Gastrointestinal Oncology
|April 3, 2023
PubMed
Summary

Colorectal cancer (CRC) screening faces challenges, but next-generation sequencing (NGS) offers advanced tools. NGS aids in identifying new genomic features and actionable targets for personalized colorectal cancer medicine.

Keywords:
Colorectal cancerColorectal cancer screeningGut microbiotaNext-generation sequencing

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Area of Science:

  • Oncology
  • Genomics
  • Medical Diagnostics

Background:

  • Colorectal cancer (CRC) is a leading global malignancy, characterized by genomic heterogeneity.
  • Existing CRC screening methods have limitations in performance and patient uptake.
  • The natural history of CRC makes it a prime candidate for effective preventive strategies.

Purpose of the Study:

  • To review historical and current diagnostic tools for colorectal cancer (CRC) screening.
  • To highlight the impact of next-generation sequencing (NGS) on CRC research and diagnostics.
  • To discuss the role of NGS in identifying novel genomic characteristics and actionable targets for personalized medicine.

Main Methods:

  • Review of existing literature on colorectal cancer (CRC) screening modalities.
  • Focus on the application and advancements of next-generation sequencing (NGS) technologies.
  • Analysis of NGS's contribution to understanding CRC genomics and carcinogenesis.

Main Results:

  • NGS has enabled the discovery of previously unknown CRC features, including links to gut microbial pathogens.
  • NGS significantly accelerates the cataloging of genomic alterations in colorectal cancer.
  • NGS facilitates the identification of novel genomic characteristics and potential therapeutic targets.

Conclusions:

  • Next-generation sequencing (NGS) is revolutionizing colorectal cancer (CRC) screening and understanding.
  • NGS provides powerful tools for identifying actionable targets for personalized CRC medicine.
  • Advancements in NGS promise improved diagnostic accuracy and therapeutic strategies for colorectal cancer.