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Age differences in plasma norepinephrine kinetics in humans.

R C Veith, J A Featherstone, O A Linares

    Journal of Gerontology
    |May 1, 1986
    PubMed
    Summary
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    Older adults have higher norepinephrine levels primarily due to increased NE appearance rate, not decreased clearance. This finding impacts understanding of aging and cardiovascular health.

    Area of Science:

    • Physiology
    • Gerontology
    • Cardiovascular Science

    Background:

    • Plasma norepinephrine (NE) levels increase with age.
    • The underlying mechanisms for elevated NE in older individuals are not fully understood.

    Purpose of the Study:

    • To investigate whether increased plasma NE in older adults results from greater NE appearance rate and/or decreased NE clearance.
    • To quantify the kinetic differences in NE metabolism between young and older healthy individuals.

    Main Methods:

    • Utilized a tritium-labeled NE isotope dilution technique to measure arterialized plasma NE kinetics.
    • Compared NE kinetics in 25 healthy young volunteers (27 ± 6 yr) and 18 healthy older volunteers (68 ± 5 yr).

    Main Results:

    Related Experiment Videos

  • Older participants exhibited 54% higher basal NE levels compared to younger individuals.
  • Plasma NE appearance rate was 32% higher, and NE clearance was 19% lower in older adults.
  • NE appearance rate significantly correlated with NE levels, explaining 57% of the variance, while clearance explained only 14%.

    • Conclusions:

    • The primary factor contributing to elevated plasma NE levels in older individuals is an increased NE appearance rate.
    • These findings highlight altered NE kinetics as a key physiological change associated with aging.