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Updated: Aug 4, 2025
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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
Published on: October 28, 2020
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BRUGADA-LIKE ECG PATTERN AND TUMORS INVOLVING RIGHT VENTRICULAR OUTFLOW TRACT - CASE SERIES AND LITERATURE REVIEW
Waldemar Elikowski1, Natalia Fertała1, Magdalena Zawodna-Marszałek1
1DEPARTMENT OF INTERNAL MEDICINE, JÓZEF STRUS HOSPITAL, POZNAN, POLAND.
Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|April 3, 2023
Summary
Mechanical heart compression from tumors can cause a Brugada-like ECG pattern. This study highlights three new cases of intracardiac metastatic tumors in the right ventricular outflow tract causing this specific electrocardiogram abnormality.
Area of Science:
- Cardiology
- Oncology
- Pathology
Background:
- Mechanical heart compression, including from mediastinal tumors, can induce a Brugada-like electrocardiogram (ECG) pattern.
- Intracardiac tumors obstructing the right ventricular outflow tract (RVOT) may also present with a Brugada-like ECG.
- Eight cases of RVOT tumors associated with Brugada-like ECG have been previously reported, including mediastinal and intracardiac locations.
Approach:
- The study presents three new cases of intracardiac metastatic tumors in the RVOT.
- These cases are associated with a Brugada-like ECG pattern, characterized by coved ST-segment elevation in right precordial leads.
Key Points:
- All patients had advanced-stage neoplastic disease with no prior cardiovascular history or arrhythmias.
- ECG findings were incidental, with no reported chest pain or elevated cardiac troponins.
- The cases involved metastatic tumors from bladder, colon, and renal cancers.
Conclusions:
- Intracardiac metastatic tumors obstructing the RVOT are a potential cause of Brugada-like ECG patterns.
- This association underscores the importance of considering cardiac involvement in patients with advanced malignancies and unexplained ECG changes.
- Further investigation is warranted to elucidate the mechanisms linking RVOT tumors to Brugada-like ECG phenomena.
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