Related Experiment Video

Updated: Aug 4, 2025

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

577

[Therapy concepts for thyroid carcinoma]

Friederike Eilsberger1, Michael C Kreissl2, Markus Luster3

  • 1Klinik für Nuklearmedizin, Universitätsklinikum Marburg, Marburg, Germany.

Laryngo- Rhino- Otologie
|April 3, 2023
PubMed

Insights

Theranostics targeting the sodium iodide symporter (NIS) are effective for differentiated thyroid cancer. However, radioiodine-refractory thyroid carcinomas (RRTC) lack NIS, necessitating novel theranostic targets for improved treatment outcomes.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Molecular Imaging

Context:

  • Differentiated thyroid carcinoma (DTC) management relies on sodium iodide symporter (NIS) theranostics.
  • Radioiodine-refractory thyroid carcinomas (RRTC) present a therapeutic challenge due to absent NIS expression.
  • Limited treatment options for RRTC necessitate the development of alternative theranostic strategies.

Purpose:

  • To explore the potential of novel theranostic targets in NIS-negative RRTC.
  • To evaluate the feasibility of targeting somatostatin receptors (SSTR) and prostate-specific membrane antigen (PSMA) in RRTC.
  • To assess the current evidence for emerging theranostic approaches in advanced thyroid cancer.

Summary:

  • The sodium iodide symporter (NIS) is a key theranostic target in differentiated thyroid carcinoma.
  • Radioiodine-refractory thyroid carcinomas (RRTC) are characterized by reduced or absent NIS expression, rendering standard theranostics ineffective.
  • Emerging strategies involve targeting alternative receptors like somatostatin receptors (SSTR) or prostate-specific membrane antigen (PSMA) in RRTC, though further evaluation is required.

Impact:

  • This research highlights the limitations of current theranostics in RRTC.
  • It identifies potential new theranostic targets for a challenging subset of thyroid cancer.
  • Further investigation into SSTR and PSMA targeting could lead to improved therapeutic outcomes for patients with RRTC.

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