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Updated: May 1, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
State-of-the-Art Theranostics of Thyroid Cancer
Michael C Kreissl1, Daniel A Hescheler1, Andreas Pfestroff2
1Division of Nuclear Medicine, Department of Radiology and Nuclear Medicine, University Magdeburg, Magdeburg, Leipziger Straße 44, 39120 Magdeburg, Germany.
Thyroid cancer theranostics have advanced with new radiopharmaceuticals targeting sodium-iodine in differentiated thyroid cancer. For aggressive subtypes, [18F]fluorodeoxyglucose PET/CT is standard, and somatostatin receptor agents are emerging options.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiopharmaceutical Therapy
Background:
- Thyroid cancer theranostics have seen significant advancements.
- Established and novel radiopharmaceuticals offer diverse treatment options.
- Sodium-iodine symporter remains a key target for differentiated thyroid cancer (DTC).
Purpose of the Study:
- To review the current landscape of thyroid cancer theranostics.
- To highlight the role of sodium-iodine targeting in DTC.
- To discuss advanced imaging and emerging theranostic approaches.
Main Methods:
- Review of established and novel radiopharmaceuticals for thyroid cancer.
- Discussion of diagnostic imaging modalities like [18F]fluorodeoxyglucose PET/CT.
- Exploration of theranostic strategies targeting somatostatin receptors.
Main Results:
- Sodium-iodine remains the primary target for differentiated thyroid cancer.
- [18F]fluorodeoxyglucose PET/CT is the gold standard for aggressive subtypes.
- Somatostatin receptor-targeted radiopharmaceuticals are emerging as viable options.
Conclusions:
- Thyroid cancer theranostics offer expanding therapeutic avenues.
- Personalized approaches utilizing specific molecular targets are crucial.
- Integration of novel radiopharmaceuticals enhances treatment efficacy.
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