Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

High-Performance Liquid Chromatography: Types of Detectors01:15

High-Performance Liquid Chromatography: Types of Detectors

664
The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte...
664
Flow Cytometry01:23

Flow Cytometry

13.3K
The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
In...
13.3K
Gas Chromatography: Types of Detectors-II01:19

Gas Chromatography: Types of Detectors-II

449
In gas chromatography, different detectors are employed to meet specific analytical needs. These detectors are often categorized based on their detection mechanisms and the types of compounds they are best suited to analyze. Thermal Conductivity Detectors (TCD), Flame Ionization Detectors (FID), and Electron Capture Detectors (ECD) represent common categories, each with unique operating principles and applications. However, beyond these, several other detectors are designed for more specialized...
449
Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

847
Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
847
Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

671
The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
671
Capillary Electrophoresis: Instrumentation01:20

Capillary Electrophoresis: Instrumentation

285
Capillary electrophoresis instrumentation typically consists of several key components. A high-voltage power supply generates the electric field necessary for the separation by connecting to an anode (the positively charged electrode) and a cathode (the negatively charged electrode) located in buffer reservoirs at each end of the capillary tube. The system includes a sample vial, a fused silica capillary tube coated with polyimide for mechanical strength through which the sample components...
285

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Silicon Dioxide Multi-Mode Interference Spectrometers.

Micromachines·2026
Same author

Review of Recent Optofluidic Devices.

Micromachines·2026
Same author

Air Core ARROW Waveguides Fabricated in a Membrane-Covered Trench.

Photonics·2025
Same author

Constrained Volume Micro- and Nanoparticle Collection Methods in Microfluidic Systems.

Micromachines·2024
Same author

Nano/microfluidic device for high-throughput passive trapping of nanoparticles.

Biomicrofluidics·2023
Same author

High-speed rotor for microparticle impact studies.

The Review of scientific instruments·2023

Related Experiment Video

Updated: Aug 4, 2025

Asymmetrical Flow Field-Flow Fractionation for Sizing of Gold Nanoparticles in Suspension
09:33

Asymmetrical Flow Field-Flow Fractionation for Sizing of Gold Nanoparticles in Suspension

Published on: September 11, 2020

6.2K

Flow-through charge detection mass spectrometry to categorize micron-sized particles.

Parker Allred1, Eric Christie1, Yixin Song1

  • 1Electrical and Computer Engineering Department, Brigham Young University, Provo, Utah 84602, USA.

The Review of Scientific Instruments
|April 4, 2023
PubMed
Summary

This study introduces a novel charge detection mass spectrometry method for precisely measuring the mass and charge of micron-sized particles. This technology is crucial for analyzing extraterrestrial dust, such as Martian dust.

More Related Videos

Mass-Sensitive Particle Tracking to Characterize Membrane-Associated Macromolecule Dynamics
13:30

Mass-Sensitive Particle Tracking to Characterize Membrane-Associated Macromolecule Dynamics

Published on: February 18, 2022

4.5K
Capillary Electrophoresis Mass Spectrometry Approaches for Characterization of the Protein and Metabolite Corona Acquired by Nanomaterials
07:54

Capillary Electrophoresis Mass Spectrometry Approaches for Characterization of the Protein and Metabolite Corona Acquired by Nanomaterials

Published on: October 27, 2020

4.5K

Related Experiment Videos

Last Updated: Aug 4, 2025

Asymmetrical Flow Field-Flow Fractionation for Sizing of Gold Nanoparticles in Suspension
09:33

Asymmetrical Flow Field-Flow Fractionation for Sizing of Gold Nanoparticles in Suspension

Published on: September 11, 2020

6.2K
Mass-Sensitive Particle Tracking to Characterize Membrane-Associated Macromolecule Dynamics
13:30

Mass-Sensitive Particle Tracking to Characterize Membrane-Associated Macromolecule Dynamics

Published on: February 18, 2022

4.5K
Capillary Electrophoresis Mass Spectrometry Approaches for Characterization of the Protein and Metabolite Corona Acquired by Nanomaterials
07:54

Capillary Electrophoresis Mass Spectrometry Approaches for Characterization of the Protein and Metabolite Corona Acquired by Nanomaterials

Published on: October 27, 2020

4.5K

Area of Science:

  • Analytical Chemistry
  • Planetary Science
  • Instrument Development

Background:

  • Accurate characterization of micron-sized particles is essential for various scientific disciplines.
  • Previous methods for measuring both charge and mass of individual particles simultaneously have limitations.

Purpose of the Study:

  • To develop and validate a charge detection mass spectrometry technique for simultaneous measurement of particle charge and mass.
  • To assess the applicability of this technique for analyzing extraterrestrial dust, specifically Martian dust.

Main Methods:

  • Utilized a flow-through instrument employing charge induction onto cylindrical electrodes connected to a differential amplifier for charge detection.
  • Determined particle mass by measuring acceleration under a controlled electric field.

Main Results:

  • Successfully measured mass and charge of micron-sized particles (30-400 fg, 3-7 µm diameter).
  • Achieved 10% accuracy for particles up to 620 fg with a charge range of 500e⁻ to 56 ke⁻.
  • Demonstrated the potential relevance of the measured charge and mass ranges for Martian dust analysis.

Conclusions:

  • The developed charge detection mass spectrometry method provides a robust tool for simultaneous particle charge and mass analysis.
  • The technique's demonstrated capabilities are highly relevant for in-situ analysis of extraterrestrial dust, including Martian dust.