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Updated: Aug 4, 2025

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A High Dynamic Range Dual 8×16 Capacitive Sensor Array for Life Science Applications.

Hamed Osouli Tabrizi, Saghi Forouhi, Ebrahim Ghafar-Zadeh

    IEEE Transactions on Biomedical Circuits and Systems
    |April 4, 2023
    PubMed
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    A new complementary metal-oxide-semiconductor (CMOS) capacitive sensor array offers a low-cost, calibration-free platform for life science applications. This multimodal sensing device enables high-throughput drug development and advanced diagnostics.

    Area of Science:

    • Electrical Engineering
    • Biomedical Engineering
    • Materials Science

    Background:

    • Existing sensing platforms often require costly calibration and lack multimodal capabilities for life science applications.
    • There is a need for integrated, low-cost, and automated sensing solutions for high-throughput drug development and diagnostics.

    Purpose of the Study:

    • To present a fully integrated complementary metal-oxide-semiconductor (CMOS) capacitive sensor array for life science applications.
    • To demonstrate a multimodal, calibration-free sensing platform with temporal, spatial, and dielectric sensing capabilities.

    Main Methods:

    • Fabrication of a 16x16 interdigitated electrodes (IDEs) array on a 0.35 μm AMS CMOS process chip.
    • Integration of charge-based readout and multiplexing circuitries on the same chip.

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  • Demonstration of functionality using chemical solvents like ethanol, methanol, and pure water.

    • Main Results:

    • Achieved a wide input capacitance range (ICR) of approximately 100 fF.
    • Demonstrated a high resolution of 150 aF.
    • Confirmed the capability for temporal, spatial, and dielectric sensing modes.

    Conclusions:

    • The developed CMOS capacitive sensor array provides a versatile, low-cost, and calibration-free sensing platform.
    • This technology advances the development of automated, multimodal capacitive sensing for high-throughput drug discovery and other life science applications.