Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

6.2K
Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
6.2K
Intracellular Movement of Viruses and Bacteria01:10

Intracellular Movement of Viruses and Bacteria

2.9K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acidified Nitrogen Self-Doped Porous Carbon with Superprotonic Conduction for Applications in Solid-State Proton Battery.

Small (Weinheim an der Bergstrasse, Germany)·2023
Same author

Selective capture of palladium from acid wastewater by thiazole-modified activated carbon: Performance and mechanism.

Environmental research·2023
Same author

The transalveolar approach with the small segmentation method for inclined maxillary sinus floor elevation: A retrospective study.

Clinical implant dentistry and related research·2023
Same author

An Overview of the Mechanisms Involved in Neuralgia.

Journal of inflammation research·2023
Same author

Tuning electronic structure of the carbon skeleton to accelerate electron transfer for promoting the capture of gold.

Environment international·2023
Same author

Engineered <i>Escherichia coli</i> Consortia Function in a Programmable Pattern for Multiple Enzymatic Biosynthesis.

ACS applied materials & interfaces·2023

Related Experiment Video

Updated: Aug 4, 2025

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
08:40

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

59.1K

Progress in the study of parvovirus entry pathway.

Jiuming Shi1, Yifeng Pei1, Qian Yu1

  • 1College of Life Sciences, Jilin Agricultural University, Changchun, 130118, Jilin Province, China.

Virology Journal
|April 4, 2023
PubMed
Summary

Parvoviruses, crucial for cancer therapy and genetic engineering, utilize specific pathways to enter the cell nucleus. Understanding these viral entry mechanisms, including nuclear localization signals and transport proteins, is key for future research.

Keywords:
Imp β participationNuclear membrane permeabilityNuclear pathwayParvovirus

More Related Videos

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

30.3K
In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation
07:24

In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation

Published on: March 27, 2016

9.0K

Related Experiment Videos

Last Updated: Aug 4, 2025

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
08:40

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

59.1K
Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

30.3K
In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation
07:24

In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation

Published on: March 27, 2016

9.0K

Area of Science:

  • Molecular Biology
  • Virology
  • Cell Biology

Background:

  • Parvoviruses are DNA viruses with applications in cancer therapy and genetic engineering.
  • Viral entry into the host cell nucleus is a critical step for infection and replication.

Purpose of the Study:

  • To discuss the various nuclear entry pathways utilized by parvoviruses.
  • To identify key proteins involved in mediating viral nuclear transport.

Main Methods:

  • Review of existing literature on parvovirus nuclear import.
  • Analysis of protein interactions, including importin-beta and nuclear localization signals.
  • Discussion of classical and alternative nuclear entry mechanisms.

Main Results:

  • Parvoviruses navigate the cytosol towards the nucleus.
  • Nuclear entry involves recognition of nuclear localization signals (NLS) by importin-beta (impβ).
  • Two primary pathways exist: the classical pathway via importin-alpha and impβ, and an alternative NPC-mediated pathway.

Conclusions:

  • The study highlights the complex mechanisms of parvovirus nuclear entry.
  • Understanding these pathways, including transient nuclear membrane dissolution, is essential for future research.
  • This provides a reference for further investigations into viral entry mechanisms and therapeutic applications.