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Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
Published on: April 30, 2021
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Newly developed 3D in vitro models to study tumor-immune interaction
Peiyuan Mu1,2,3,4, Shujuan Zhou1,2,3,4, Tao Lv1,2,3,4
1Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Journal of Experimental & Clinical Cancer Research : CR
|April 4, 2023
Summary
Three-dimensional (3D) in vitro models are revolutionizing tumor immunology research and cancer treatment. These advanced models offer new avenues for personalized medicine, immunotherapy optimization, and adoptive cell therapy development.
Area of Science:
- Oncology
- Immunology
- Biotechnology
Background:
- Immunotherapy has transformed cancer treatment, driving significant advancements in tumor immunology research.
- Three-dimensional (3D) in vitro models are increasingly vital for maintaining tumor cells in a near-native state, aiding oncology studies.
Purpose of the Study:
- To review commonly used 3D in vitro models in tumor immunology research.
- To summarize the applications of these models in personalized treatment, immunotherapy optimization, and adoptive cell therapy.
- To analyze current limitations and future prospects of 3D in vitro models.
Main Methods:
- Introduction of established 3D in vitro models.
- Summary of applications in tumor immunology.
- Analysis of model shortcomings and future outlook.
Main Results:
- 3D culture methods like organoid co-culture, ALI culture, 3D-microfluidic culture, and 3D-bioprinting provide novel approaches for tumor immunology studies.
- These models are applicable to personalized treatment, immunotherapy optimization, and adoptive cell therapy.
Conclusions:
- 3D in vitro models are powerful tools for advancing tumor immunology research and cancer therapy.
- Further development of these models holds promise for improved personalized medicine and immunotherapeutic strategies.
