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Recent Progress on Cyclic Peptides' Assembly and Biomedical Applications.

Chongyang Wu1, Huaimin Wang1

  • 1Department of Chemistry, School of Science, Westlake University, No. 600 Dunyu Road, Hangzhou, 310024, Zhejiang Province, P. R. China.

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|April 5, 2023
PubMed
Summary
This summary is machine-generated.

Cyclic peptides self-assemble into nanotubes and gels for advanced materials. Stimuli-triggered assembly and peptide-polymer conjugates show promise in drug delivery and disease targeting applications.

Keywords:
cyclic peptidesdrug deliverynanomedicinepeptide polymersself-assembly

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Area of Science:

  • Biomaterials Science
  • Supramolecular Chemistry

Background:

  • Cyclic peptides are versatile building blocks with significant structural and functional roles in materials science.
  • Their inherent biophysical advantages make them attractive for developing novel functional materials.

Purpose of the Study:

  • To provide an overview of self-assembling cyclic peptides, focusing on nanotube formation.
  • To summarize recent advancements in stimuli-triggered cyclic peptide assembly and peptide-polymer conjugates.
  • To highlight their applications in drug delivery and disease targeting.

Main Methods:

  • Review of literature on cyclic peptide self-assembly into nanotubes.
  • Analysis of stimuli-responsive cyclic peptide systems.
  • Exploration of peptide-polymer conjugate construction with alternative chirality.
  • Summary of cyclic peptides as gelators in drug delivery.

Main Results:

  • Identification of cyclic peptide types capable of self-assembling into nanotubes.
  • Progress in stimuli-triggered assembly for controlled material formation.
  • Development of peptide-polymer conjugates with tunable properties.
  • Demonstration of cyclic peptides as effective gelators for drug delivery.

Conclusions:

  • Cyclic peptides offer adaptable systems for drug delivery and selective disease targeting.
  • Stimuli-triggered cyclic peptides and their conjugates are crucial for advanced biomedical applications.
  • Self-assembly properties of cyclic peptides pave the way for innovative therapeutic strategies.