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Western diet influences on microbiome and carcinogenesis
Rachel Newsome1, Ye Yang1, Christian Jobin2
1Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
Seminars in Immunology
|April 5, 2023
Summary
The Western diet significantly impacts gut microbiota, influencing cancer development. Understanding this complex relationship is crucial for health and disease prevention strategies.
Area of Science:
- Microbiology
- Oncology
- Nutrition Science
Background:
- Intestinal microbiota composition is influenced by factors like stress, inflammation, age, lifestyle, and nutrition.
- These factors are linked to cancer susceptibility.
- Diet plays a dual role, affecting microbiota and providing compounds that interact with host systems.
Purpose of the Study:
- To review the interplay between Western diet, gut microbiota, and cancer development.
- To dissect key dietary components and their influence.
- To understand the relationship using human and pre-clinical data.
Main Methods:
- Literature review focusing on Western diet.
- Analysis of human intervention studies.
- Examination of pre-clinical research data.
Main Results:
- Western diet alters gut microbiota composition and function.
- Microbiota-derived compounds from diet influence host immunity, neurology, and hormones.
- Dietary patterns are associated with cancer risk via microbiota modulation.
Conclusions:
- A holistic approach is necessary to understand diet's effect on health and disease.
- Further research is needed to clarify the complex interactions between diet, microbiota, and cancer.
- Highlighting progress and limitations in current research is essential.
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