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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Factors Influencing Drug Absorption: Drug Dissolution01:27

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The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
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Factors Influencing Drug Absorption: Physicochemical Parameters01:22

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The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
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Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
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Texture analysis - A versatile tool for pharmaceutical evaluation of solid oral dosage forms.

Cătălina Bogdan1, Dana Hales2, Andreea Cornilă2

  • 1Department of Dermopharmacy and Cosmetics, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 12 I. Creangă Street, 400010 Cluj-Napoca, Romania.

International Journal of Pharmaceutics
|April 5, 2023
PubMed
Summary
This summary is machine-generated.

Texture analysis (TA) is crucial for characterizing solid oral dosage forms. This review guides researchers in selecting optimal TA methods for drug development, addressing challenges due to varied protocols and lack of standards.

Keywords:
Disintegration timeIn vitro – in vivo correlationMechanical characterizationMucoadhesion characterizationSolid oral dosage formsTexture analysis

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Biomedical Engineering

Background:

  • Texture analysis (TA) has become increasingly important for characterizing solid oral dosage forms.
  • Numerous scientific publications detail TA methods for evaluating diverse pharmaceutical products.
  • This review focuses on TA applications for intermediate and finished oral pharmaceutical products.

Purpose of the Study:

  • To summarize the use of TA in characterizing solid oral dosage forms.
  • To provide guidance on selecting optimal TA methodologies for drug development.
  • To address challenges arising from the lack of pharmacopoeial standards and experimental variability.

Main Methods:

  • Review of various TA methods applied to pharmaceutical products.
  • Focus on applications in mechanical characterization, mucoadhesion testing, and disintegration time estimation.
  • Consideration of in vivo specific features of oral dosage forms.

Main Results:

  • TA is a versatile tool for evaluating mechanical properties, mucoadhesion, and disintegration.
  • Significant variability exists in reported TA results due to differing experimental conditions and protocols.
  • The selection of appropriate TA testing protocols and parameters is challenging but critical.

Conclusions:

  • TA offers valuable insights into the quality attributes of oral dosage forms.
  • Standardization of TA methods and parameters is needed for consistent and reliable results.
  • This work aims to assist scientists and quality assurance professionals in choosing suitable TA techniques for drug development and quality control.