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Updated: Aug 4, 2025
Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
Published on: June 29, 2018
Narrowband gamma oscillations propagate and synchronize throughout the mouse thalamocortical visual system
Donghoon Shin1, Kayla Peelman2, Anthony D Lien2
1Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA; Electrical and Computer Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA; Bioengineering, UCSF - UC Berkeley Joint PhD Program, San Francisco, CA, USA.
None:
Oscillations of neural activity permeate sensory systems. In the visual system, broadband gamma oscillations (30-80 Hz) are thought to act as a communication mechanism underlying perception. However, these oscillations show widely varying frequency and phase, providing constraints for coordinating spike timing across areas. Here, we examined Allen Brain Observatory data and performed causal experiments to show that narrowband gamma (NBG) oscillations (50-70 Hz) propagate and synchronize throughout the awake mouse visual system. Lateral geniculate nucleus (LGN) neurons fired precisely relative to NBG phase in primary visual cortex (V1) and multiple higher visual areas (HVAs). NBG neurons across areas showed a higher likelihood of functional connectivity and stronger visual responses; remarkably, NBG neurons in LGN, preferring bright (ON) versus dark (OFF), fired at distinct NBG phases aligned across the cortical hierarchy. NBG oscillations may thus serve to coordinate spike timing across brain areas and facilitate communication of distinct visual features during perception.
