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Effective drug discovery in Chagas disease
1Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA.
Trends in Parasitology
|April 6, 2023
Summary
A novel benzoxaborole compound shows promise for treating Chagas disease, achieving parasitological cure in animal models. This discovery offers a potential breakthrough after decades of stagnation in Chagas disease therapeutics.
Area of Science:
- Neglected tropical diseases
- Medicinal chemistry
- Parasitology
Background:
- Chagas disease has lacked new therapeutic advancements for over 50 years.
- Current treatments for Chagas disease are limited and can have significant side effects.
Purpose of the Study:
- To present the discovery process of a novel benzoxaborole compound, AN15368, for Chagas disease treatment.
- To provide insights into drug discovery for Chagas disease, facilitating future clinical candidate identification.
Main Methods:
- Utilized a combination of host and parasite biology understanding.
- Employed expertise in designing and validating chemical entities.
- Tested a benzoxaborole compound in experimental Chagas disease models.
Main Results:
- The benzoxaborole compound, AN15368, achieved consistent parasitological cure in experimentally infected mice.
- The compound also demonstrated efficacy in naturally infected non-human primates (NHPs).
Conclusions:
- The reported results significantly de-risk the progression of AN15368 into human clinical trials.
- The discovery process highlights the importance of interdisciplinary approaches in developing new Chagas disease therapies.
