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Related Concept Videos

Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...

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Systemic investigations in dry eye disease.

Sharon D'Souza1, Edwin James2, Ramesh Jois3

  • 1Department of Cornea and Refractive Surgery, Narayana Nethralaya Eye Hospital, Bengaluru, Karnataka, India.

Indian Journal of Ophthalmology
|April 7, 2023
PubMed
Summary

Dry eye disease is increasing, especially severe cases potentially linked to systemic conditions like Sjogren's syndrome. This guide offers an algorithmic approach for effective diagnosis and treatment.

Keywords:
Clinical relevancedry eye diseaseinvestigationssystemic DED

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Immunology

Background:

  • Increasing incidence of dry eye disease (DED) necessitates evaluation for underlying systemic causes.
  • Severe DED cases may indicate systemic associations, such as Sjogren's syndrome.
  • Understanding diverse etiopathogenesis is crucial for effective DED management.

Purpose of the Study:

  • To provide an algorithmic approach for evaluating systemic associations in severe dry eye disease.
  • To clarify diagnostic investigations and prognostication strategies for complex DED cases.
  • To integrate ocular and systemic perspectives for comprehensive patient care.

Main Methods:

  • Review of current literature on DED and systemic associations.
  • Development of a diagnostic algorithm for severe DED.
  • Integration of clinical insights from ophthalmology and rheumatology.

Main Results:

  • Identification of key systemic conditions associated with severe DED.
  • Outline of a step-wise diagnostic pathway for evaluating systemic involvement.
  • Guidance on appropriate investigations and prognostic indicators.

Conclusions:

  • An algorithmic approach simplifies the evaluation of systemic associations in severe DED.
  • Early identification and management of systemic drivers improve DED outcomes.
  • Multidisciplinary collaboration enhances patient care for complex dry eye conditions.