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Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Risk management of skin sensitisers: A commentary.

David A Basketter1

  • 1DABMEB Consultancy Ltd, Kingswood, Gloucestershire, GL12 8RN, UK.

Regulatory Toxicology and Pharmacology : RTP
|April 7, 2023
PubMed
Summary

Allergic contact dermatitis (ACD) management has improved through better hazard identification and risk assessment. Targeted regulations, like those for fragrances, are more effective than broad bans for protecting public health.

Keywords:
Risk assessmenRisk managementSkin sensitisation

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Area of Science:

  • Toxicology
  • Dermatology
  • Regulatory Science

Background:

  • Allergic contact dermatitis (ACD) historically drove improvements in chemical hazard identification and risk assessment.
  • Regulatory strategies, including substance bans, have been implemented to manage ACD risks.
  • The fragrance industry is a significant source of ACD, necessitating risk management measures.

Purpose of the Study:

  • To evaluate the effectiveness of hazard identification and risk assessment in managing ACD.
  • To analyze the impact of regulatory strategies on ACD prevalence.
  • To discuss the benefits of targeted versus broad regulatory controls for sensitisers.

Main Methods:

  • Review of historical data on ACD and regulatory actions.
  • Analysis of hazard identification and risk assessment validation processes.
  • Examination of diagnostic patch testing feedback from dermatology clinics.
  • Assessment of regulatory approaches, including bans and restrictions, particularly in the fragrance industry.

Main Results:

  • Validated hazard identification methods improve accuracy and facilitate quantitative risk assessment.
  • Diagnostic patch testing provides crucial feedback for refining risk assessment and management.
  • Targeted regulations and restrictions, especially for fragrance ingredients, have been implemented.
  • Sophisticated tools for aggregate exposure assessment lead to adapted risk assessments and updated usage limits.

Conclusions:

  • Targeted regulatory control of specific sensitisers is preferable to undifferentiated bans.
  • Effective risk management requires continuous adaptation of assessment tools and regulatory strategies.
  • While targeted controls may not yield immediate widespread clinical changes, they minimize unwarranted socio-economic impacts.