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Updated: Aug 3, 2025

Intralymphatic Immunotherapy and Vaccination in Mice
Published on: February 2, 2014
Preventative Care in Scleroderma: What Is the Best Approach to Vaccination?
Leonardo Martin Calderon1, Janet E Pope2, Ami A Shah3
1Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Abstract:
Systemic sclerosis (SSc) is a rare multisystem autoimmune disease characterized by fibrosis, vasculopathy, and autoimmunity. There are multiple complications inherent to SSc and its management. One of these complications is increased infection risk, which can lead to decreased quality of life and increased morbidity and mortality. Patients with SSc have lower vaccination rates and decreased vaccine seroconversion secondary to immunosuppressive medications compared with the general population. The purpose of this review is to provide clinicians with an approach to vaccinations in SSc.
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