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Association between birth by caesarian section and anxiety, self-harm: a gene-environment interaction study using UK
Yumeng Jia1, Shiqiang Cheng1, Li Liu1
1Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China.
BMC Psychiatry
|April 7, 2023
Summary
Caesarian section (CS) birth is linked to increased adult anxiety and self-harm risks. Genetic analysis identified specific genes interacting with CS birth that may influence these mental health outcomes.
Area of Science:
- Genetics
- Psychiatry
- Epidemiology
Background:
- Limited research exists on the genetic factors linking caesarian section (CS) birth to adult anxiety and self-harm.
- Understanding these mechanisms is crucial for mental health research.
Purpose of the Study:
- To investigate the association between CS birth and adult anxiety/self-harm.
- To identify genes that interact with CS birth in relation to anxiety and self-harm risk.
Main Methods:
- Utilized the UK Biobank cohort for observational analysis.
- Employed logistic regression to assess CS birth associations with anxiety and self-harm.
- Conducted genome-wide by environment interaction study (GWEIS) to find interacting genes.
Main Results:
- CS birth showed significant associations with increased adult anxiety (OR=1.24) and self-harm (OR=1.12).
- GWEIS identified suggestive genes (e.g., DKK2, ATXN1) interacting with CS birth for anxiety.
- Significant gene-environment interactions were found for self-harm involving genes such as ALDH1A2 and DAB1.
Conclusions:
- CS birth is associated with higher risks of adult anxiety and self-harm.
- Identified genes interacting with CS birth may offer new insights into the pathogenesis of these mental health conditions.
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