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Updated: Aug 3, 2025

Corticospinal Excitability Modulation During Action Observation
Published on: December 31, 2013
Observational studies - The Cinderella of the Italian research system
Celeste Cagnazzo1, Marco Basiricò1, Federica Palermo2
1Dipartimento Patologia e Cura del Bambino, Regina Margherita AOU Città della Salute e della Scienza di Torino, Presidio Infantile Regina Margherita, Turin, Italy.
Abstract:
Observational trials are crucial to assess the generalizability in the real world of evidence deriving from registration studies. Despite the unquestionable importance of this type of studies, Italian researchers have had to face many obstacles over the years, mainly due to ambiguous definitions and to a complex but at the same time incomplete legislation. The regulatory adjustments to the European Regulation 536/2014 have further complicated the operating and operational framework, making observational research a real "Cinderella" of the Italian system.
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