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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Updated: Aug 3, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Segmental Darier's disease: A case report.

Elena Pastukhova1, Lauren LaBerge1,2

  • 1Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.

SAGE Open Medical Case Reports
|April 10, 2023
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Summary
This summary is machine-generated.

Segmental Darier's disease, a rare genetic skin disorder, presents as a localized rash along Blaschko lines. Treatment with oral retinoids like acitretin can significantly improve patient outcomes.

Keywords:
Segmental Darier’s diseaseepidemiologygenodermatosismosaicism

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Area of Science:

  • Dermatology
  • Genetics
  • Molecular Biology

Background:

  • Darier's genodermatosis is a rare inherited skin disorder.
  • Segmental Darier's disease is an uncommon subtype caused by early embryogenesis mutations in ATPase type 2.
  • It manifests as a pruritic, papular eruption following Blaschko lines.

Observation:

  • Histopathology reveals acantholysis, dyskeratosis, and corps ronds.
  • Segmental Darier's disease can mimic other acantholytic Blaschkolinear dermatoses.
  • A 48-year-old male presented with chronic localized papular eruption in a Blaschkoid distribution.

Findings:

  • The patient was diagnosed with segmental Darier's disease.
  • Significant clinical improvement was observed after treatment with acitretin.
  • This highlights the efficacy of systemic retinoid therapy in managing this condition.

Implications:

  • Accurate clinical and histological recognition of segmental Darier's disease is crucial for appropriate management.
  • Early diagnosis and treatment can prevent disease progression and improve quality of life.
  • Further research into genetic mutations and targeted therapies for Darier's genodermatosis subtypes is warranted.