In vivo experiments with the excimer laser--technical parameters and healing processes

Area of Science:

• Ophthalmology
• Laser Surgery
• Biomedical Engineering

Background:

• Excimer lasers are utilized in refractive surgery.
• Optimizing laser parameters and delivery systems is crucial for corneal procedures.

Purpose of the Study:

• To evaluate the efficacy of excimer laser (193 nm) in vivo for corneal surgery on rabbit models.
• To introduce and assess a novel total-reflecting prism delivery system.
• To determine optimal laser parameters, specifically repetition rate, for corneal reshaping.

Main Methods:

• In vivo experimentation on rabbit corneae using a 193 nm excimer laser.
• Utilization of a new delivery system incorporating total-reflecting prisms.
• Observation and documentation of corneal healing processes post-laser application.

Main Results:

• A repetition rate of approximately 50 Hz was identified as optimal for corneal surgery.
• The new prism-based delivery system was successfully implemented.
• Demonstration of corneal healing processes following excimer laser treatment.
• Observation that excimer laser incisions may require less depth than traditional knife-induced incisions to alter corneal curvature.

Conclusions:

• The excimer laser, coupled with a novel prism delivery system, offers a viable approach for corneal surgery.
• A 50 Hz repetition rate appears to be the most effective parameter for achieving desired corneal curvature changes.
• Excimer laser surgery may allow for shallower incisions compared to conventional methods, potentially improving patient outcomes.