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Perioperative Management of a Patient with Hemophilia C and Allergy to Fresh Frozen Plasma

Sara Kianian1, Giacomo Scorsese1, Eric Zabirowicz1

  • 1Department of Anesthesiology, Stony Brook University Health Science Center, Stony Brook, NY 11794-8480, USA.

Case Reports in Anesthesiology
|April 10, 2023
PubMed

Hemophilia C is a rare bleeding disorder characterized by a deficiency in clotting factor XI (fXI) and has no standard of care for preoperative optimization before cardiac surgery. Normalization of fXI levels in patients with hemophilia C can be achieved with fresh frozen plasma (FFP), which sometimes results in allergic reactions. We present a case of a patient with hemophilia C requiring coronary artery bypass grafting surgery who developed an allergic reaction to FFP. Our report underscores the balance between thrombosis and bleeding risks when devising a perioperative plan for patients with hemophilia C.

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