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Updated: Aug 3, 2025

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
Published on: September 15, 2023
Role of T-box transcription factor 3 in gastric cancers
Naoki Asano1, Akira Imatani2, Akio Takeuchi2
1Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan. asanon@med.tohoku.ac.jp.
Abstract:
The expression of T-box transcription factor 3 (TBX3) has been identified in various cancers, including gastric cancers. Its role in breast cancers and melanomas has been intensively studied, and its contribution to the progression of cancers through suppressing senescence and promoting epithelial-mesenchymal transition has been reported. Recent reports on the role of TBX3 in gastric cancers have implied its involvement in gastric carcinogenesis. Considering its pivotal role in the initiation and progression of cancers, TBX3 could be a promising therapeutic target for gastric cancers.
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