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Related Experiment Video

Updated: Aug 3, 2025

Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
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Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography

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Longitudinal choroidal thickness changes among Chinese young adults with various refractive errors.

Fang Duan1, Ziyan Chen1, Zhenyu Wang1

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.

Frontiers in Medicine
|April 10, 2023
PubMed
Summary

Longitudinal choroidal thickness (CT) changes varied by refractive error in young Chinese adults over two years. Baseline CT, not axial length, predicted future CT changes.

Keywords:
choroid thicknessparafovealrefractive errorsubfovealyoung adult

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Area of Science:

  • Ophthalmology
  • Optometry
  • Biomedical Engineering

Background:

  • Refractive errors are a growing global health concern.
  • Understanding ocular changes in young adults is crucial for myopia management.
  • Choroidal thickness (CT) and axial length (AL) are key ocular parameters.

Purpose of the Study:

  • To investigate longitudinal changes in choroidal thickness (CT) and axial length (AL).
  • To analyze these changes in relation to refractive error status in Chinese young adults.
  • To identify factors influencing CT and AL over a two-year period.

Main Methods:

  • A two-year prospective cohort study involving 291 Chinese medical freshmen (aged 18-22).
  • Ocular examinations included cycloplegic refraction, ocular biometry, and swept-source OCT for macular CT.
  • Measurements were taken at baseline and follow-up visits.

Main Results:

  • Significant baseline differences in CT and AL existed among emmetropia, mild/moderate, and high myopia groups.
  • Subfoveal and parafoveal CT changes differed significantly between emmetropia and myopia groups over two years.
  • Changes in CT were significantly associated with baseline subfoveal CT, but not with baseline AL, age, or gender.

Conclusions:

  • Longitudinal CT changes in young Chinese adults are influenced by refractive error.
  • Baseline subfoveal CT is a significant predictor of its own longitudinal changes.
  • Axial length does not appear to be a significant factor in predicting CT changes in this cohort.