Infectious Complications and Antibiotic Use in Gastroschisis

Area of Science:

• Neonatal surgery
• Pediatric infectious diseases

Background:

• Gastroschisis is a complex congenital defect with high rates of infection, morbidity, and mortality.
• Infection affects up to two-thirds of gastroschisis patients, significantly increasing complications.

Purpose of the Study:

• To review infection risks and antibiotic management in gastroschisis.
• To provide evidence-based recommendations for antibiotic use in neonates with gastroschisis.

Main Methods:

• Literature review of studies on gastroschisis and infection.
• Analysis of factors associated with increased infection risk.
• Evaluation of current antibiotic usage patterns.

Main Results:

• Increased central venous catheter days, complex gastroschisis, and delayed closure correlate with higher infection rates.
• Sutureless gastroschisis closure is linked to reduced infection incidence.
• Antibiotic use in gastroschisis management is highly variable.

Conclusions:

• Selective, short-term antibiotic therapy is advised for simple gastroschisis, irrespective of closure method.
• Developing evidence-based guidelines is crucial to standardize care and improve outcomes.
• Reducing variability in care can enhance patient outcomes across institutions.