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Inside-out: Antibody-binding reveals potential folding hinge-points within the SARS-CoV-2 replication co-factor nsp9

Yue Pan1, Indu R Chandrashekaran1, Luke Tennant2

  • 1Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

Plos One
|April 10, 2023
PubMed
Summary

Nanobodies targeting SARS-CoV-2 Nsp9 reveal its unique fold and flexibility. Binding to Trp-53 induces significant structural changes, offering insights into coronaviral replication mechanisms.

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