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Updated: Aug 3, 2025

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
Published on: May 27, 2015
Mast Cells and Resistance to Immunotherapy in Cancer
1Department of Translational Biomedicine and Neuroscience, University of Bari Medical School, Piazza Giulio Cesare, 11, 70125, Bari, Italy. domenico.ribatti@uniba.it.
Abstract:
Mast cells are involved in tumor growth and their mediators exert both pro- and anti-tumorigenic roles in different human cancers. The identification of defined immunosuppressive pathways that are present in the tumor microenvironment has pointed therapeutic strategies that may promote inflammation and/or innate immune activation in this context. Mast cells can contribute to the immune suppressive tumor microenvironment and may also enhance anti-tumor responses. This review article is focused on the analysis of the mechanisms of the role of mast cells in resistance to immunotherapy in cancer.
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