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Updated: Aug 3, 2025

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
Efficient and Low-Impact Acetalization Reactions in Deep Eutectic Solvents
Davide Arnodo1, Carolina Meazzo1, Salvatore Baldino1
1Dipartimento di Chimica, Università degli Studi di Torino, Via Pietro Giuria 7, 10125, Torino, Italy.
Abstract:
The synthesis of acetals in acidic natural deep eutectic solvents (NADES), in which the solvent itself participates in the catalytic promotion of the reaction, is reported herein. The reaction is performed under feasible conditions, open air, without the need of external additives, catalysts or water-removing techniques, and it is wide in scope. The products are easily recovered, and the reaction medium is fully recycled and reused without weakening of its catalytic activity after 10 times. Remarkably, the entire process has been realized on gram scale.
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