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Related Concept Videos

Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Related Experiment Video

Updated: Aug 3, 2025

An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation
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An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation

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Metastatic dormancy needs STING.

Amy E Baek1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling
|April 11, 2023
PubMed
Summary

Stimulator of interferon genes (STING) activation within cancer cells halts the advancement of dormant metastatic disease. This finding highlights STING

Area of Science:

  • Immunology
  • Oncology
  • Cancer Metastasis

Background:

  • Metastasis is a complex process involving cancer cell dissemination and survival.
  • Dormant metastatic cells can evade immune surveillance and treatment.
  • The role of STING signaling in regulating metastatic dormancy is not fully understood.

Purpose of the Study:

  • To investigate the role of STING activation in preventing the progression of dormant metastasis.
  • To determine the mechanisms by which STING signaling impacts metastatic cell fate.

Main Methods:

  • Utilized genetically engineered mouse models of cancer metastasis.
  • Employed in vivo imaging techniques to track dormant metastatic lesions.
  • Analyzed STING pathway activation in cancer cells using molecular biology assays.

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An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth
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A Time-lapse, Label-free, Quantitative Phase Imaging Study of Dormant and Active Human Cancer Cells
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Related Experiment Videos

Last Updated: Aug 3, 2025

An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation
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An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth
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A Time-lapse, Label-free, Quantitative Phase Imaging Study of Dormant and Active Human Cancer Cells

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Main Results:

  • STING activation in cancer cells significantly reduced the outgrowth of dormant micrometastases.
  • Enhanced STING signaling led to increased apoptosis of metastatic cancer cells.
  • Tumor-intrinsic STING activity was crucial for preventing metastatic progression.

Conclusions:

  • STING activation in cancer cells serves as a critical barrier against the progression of dormant metastasis.
  • Targeting the STING pathway represents a potential therapeutic strategy to control metastatic disease.