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Updated: Aug 3, 2025

Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
Circulating Long Noncoding RNA Signatures Associate With Incident Diabetes in Older Adults: A Prospective Analysis
Florian A Wenzl1, Alessandro Mengozzi2,3,4, Shafeeq A Mohammed2
1Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland.
Objective:
Long noncoding RNAs (lncRNAs) are involved in diabetogenesis in experimental models, yet their role in humans is unclear. We investigated whether circulating lncRNAs associate with incident type 2 diabetes in older adults.
Research Design And Methods:
A preselected panel of lncRNAs was measured in serum of individuals without diabetes (n = 296) from the Vienna Transdanube Aging study, a prospective community-based cohort study. Participants were followed up over 7.5 years. A second cohort of individuals with and without type 2 diabetes (n = 90) was used to validate our findings.
Results:
Four lncRNAs (ANRIL, MIAT, RNCR3, and PLUTO) were associated with incident type 2 diabetes and linked to hemoglobin A1c trajectories throughout the 7.5-year follow-up. Similar results (for MIAT and PLUTO also in combined analysis) were obtained in the validation cohort.
Conclusions:
We found a set of circulating lncRNAs that independently portends incident type 2 diabetes in older adults years before disease onset.
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