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Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
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Prognostic impact of cardiohepatic syndrome in patients with ST-segment elevation myocardial infarction

Mustafa A Sungur1, Aylin Sungur2, Ali Karagöz3

  • 1Department of Cardiology, Dr. Siyami Ersek Thoracic & Cardiovascular Surgery Education Research Hospital, Selimiye Mh. Tıbbiye Cd. No: 25 Üsküdar, İstanbul, Turkey.

Biomarkers in Medicine
|April 12, 2023
PubMed

Insights

Cardiohepatic syndrome (CHS) significantly increases mortality risk in ST-segment elevation myocardial infarction (STEMI) patients. Early CHS evaluation is crucial for risk stratification and improving patient outcomes.

Area of Science:

  • Cardiology
  • Hepatology
  • Internal Medicine

Background:

  • Cardiohepatic syndrome (CHS) describes the complex interplay between cardiac and liver function.
  • Understanding CHS is vital, particularly in acute cardiovascular events.

Purpose of the Study:

  • To assess the impact of CHS on mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention.
  • To identify CHS as a prognostic factor in STEMI.

Main Methods:

  • A cohort of 1541 STEMI patients who underwent primary percutaneous coronary intervention was analyzed.
  • CHS was diagnosed by elevated levels of at least two of three cholestatic liver enzymes: total bilirubin, alkaline phosphatase, and gamma-glutamyl transferase.

Main Results:

  • CHS was identified in 144 (9.34%) of the studied STEMI patients.
  • Multivariate analysis confirmed CHS as an independent predictor of both in-hospital (OR: 2.48) and long-term mortality (HR: 2.4).

Conclusions:

  • The presence of CHS is associated with a poorer prognosis in STEMI patients.
  • CHS should be incorporated into the risk stratification protocols for STEMI patients.

Keywords:
ST-segment elevation myocardial infarctioncardiohepatic syndromein-hospital mortalitylong-term mortality

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