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Related Concept Videos

Teratogenicity01:07

Teratogenicity

2.6K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Updated: Aug 3, 2025

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
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CHRONIC EFFECTS OF CADMIUM CHLORIDE ON RAT EMBRYOGENESIS.

M Kozyk1, A Wahl2, K Strubchevska1

  • 11Internal Medicine, Corewell Health William Beaumont University Hospital, Royal Oak, USA.

Georgian Medical News
|April 12, 2023
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Summary
This summary is machine-generated.

Cadmium toxicity harms rat embryogenesis. However, co-administration of zinc, cerium, or selenium nanocomposite citrates significantly counteracted these adverse effects, protecting fetal development.

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Area of Science:

  • Toxicology
  • Developmental Biology
  • Environmental Health

Background:

  • Cadmium exposure is a significant environmental concern.
  • While cadmium's impact on postnatal development is documented, its effects on embryogenesis remain understudied.
  • Understanding cadmium's embryotoxic potential is crucial for risk assessment.

Purpose of the Study:

  • To investigate the embryotoxic effects of cadmium chloride in Wistar rats.
  • To evaluate the potential protective roles of zinc citrate, cerium citrate, and a selenium nanocomposite against cadmium-induced embryotoxicity.
  • To analyze the impact on key reproductive parameters like live fetuses, corpora lutea, and implantation losses.

Main Methods:

  • Pregnant Wistar rats were administered daily doses of cadmium chloride (1.0 mg/kg).
  • Experimental groups received cadmium chloride combined with zinc citrate, cerium citrate, or a nanocomposite (iodine, sulfur, selenium citrates).
  • A control group received distilled water; operational interventions assessed reproductive outcomes on gestation days 13 and 20.

Main Results:

  • Cadmium chloride alone significantly reduced the number of live fetuses, indicating pronounced embryotoxicity.
  • Groups receiving cadmium chloride with zinc citrate, cerium citrate, or the nanocomposite showed increased live fetuses and corpora lutea.
  • These combined treatments also resulted in decreased pre- and post-implantation losses compared to cadmium alone.

Conclusions:

  • Cadmium chloride exhibits significant embryotoxic effects in rats.
  • Zinc citrate, cerium citrate, and the selenium nanocomposite demonstrate a compensatory effect, mitigating cadmium-induced embryotoxicity.
  • These heavy metal citrates reduce cadmium's adverse impact on embryogenesis and its bodily accumulation.