Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mimetic Core-Sheath Silk Sutures with Superior-Strength for Pain Management, Anti-Infection and Wound Healing.

Advanced healthcare materials·2026
Same author

Can transformational leadership be associated with innovation among hotel employees? A dual examination of the mediating role of psychological empowerment and the moderating role of perceived organizational support.

Frontiers in psychology·2026
Same author

Association between air pollution and incident cardiovascular diseases among a population with cardiovascular-kidney-metabolic syndrome stages 0-3: the first evidence from the China Health and Retirement Longitudinal Study.

Frontiers in endocrinology·2026
Same author

hUC-MSC-exosomes deliver Let-7b/7f-5p to dermal papilla cells for a multi-target synergistic treatment of androgenetic alopecia.

Journal of nanobiotechnology·2026
Same author

A three-gene signature (ABCE1, ATAD5, FUT4) for colorectal cancer prognosis: integrative analysis of transcriptomic, single-cell, and machine learning data.

Biochemical and biophysical research communications·2026
Same author

Development and validation of a comprehensive in vitro organ model for androgenetic alopecia.

BMC biotechnology·2026

Related Experiment Video

Updated: Aug 3, 2025

Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices
07:53

Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices

Published on: April 1, 2016

7.7K

Reversible adhesives with controlled wrinkling patterns for programmable integration and discharging.

Yi Zhou1,2, Lunan Yang1, Zhen Liu1

  • 1Department of Plastic and Aesthetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P.R. China.

Science Advances
|April 12, 2023
PubMed
Summary

Researchers developed a novel switchable hydrogel film adhesive using pattern-tunable wrinkles for controlled tissue adhesion and detachment. This minimally invasive adhesive aids wound healing and can be easily removed after integration.

More Related Videos

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles
12:33

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

Published on: February 4, 2013

21.8K
Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
08:50

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Published on: September 2, 2015

8.9K

Related Experiment Videos

Last Updated: Aug 3, 2025

Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices
07:53

Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices

Published on: April 1, 2016

7.7K
Origami Inspired Self-assembly of Patterned and Reconfigurable Particles
12:33

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

Published on: February 4, 2013

21.8K
Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
08:50

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Published on: September 2, 2015

8.9K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Adhesive Technology

Background:

  • Minimally invasive tissue adhesives are crucial for medical applications but achieving on-demand adhesion and detachment remains challenging.
  • Current methods often lack precise control over adherence and removal, limiting their clinical utility.
  • Developing switchable adhesives with tunable properties is essential for advancing wound repair strategies.

Purpose of the Study:

  • To fabricate a switchable hydrogel film adhesive with pattern-tunable wrinkles to control tissue adhesion and detachment.
  • To investigate the mechanism of adhesion regulation through wrinkling pattern transitions.
  • To evaluate the efficacy of the hydrogel adhesive in a random skin flap model for wound repair.

Main Methods:

  • Fabrication of a bilayer hydrogel system designed to generate self-similar wrinkling patterns under compressive stress.
  • Characterization of wrinkling patterns at short and long wavelengths to correlate with interfacial adhesion.
  • Establishment of a random skin flap model to assess the adhesive's performance in tissue sealing and wound healing.
  • Evaluation of neovascularization and the dynamic wrinkling pattern transition for controlled detachment and ejection.

Main Results:

  • The developed hydrogel adhesive demonstrated tunable adhesion through pattern-tunable wrinkles.
  • The adhesive provided sufficient initial adhesion for tissue sealing and promoted early-stage neovascularization.
  • A dynamic wrinkling pattern transition facilitated gradual detachment and ejection of the gel film post-integration.
  • Successful application in a random skin flap model validated its potential for wound repair.

Conclusions:

  • Pattern-tunable wrinkles in a switchable hydrogel film offer a novel mechanism for controlling bioadhesion.
  • This technology provides a promising solution for minimally invasive tissue adhesion with on-demand detachment.
  • The findings offer insights into designing advanced bioadhesives for tissue engineering and regenerative medicine applications.