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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
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Bilateral Optic Neuropathy in Association with Diffuse Cutaneous Systemic Sclerosis with Interstitial Lung Disease
Nishi Prasad1, Aditi Dubey1, Kavita Kumar1
1Department of Ophthalmology, Gandhi Medical College, Bhopal, India.
Ocular Immunology and Inflammation
|April 12, 2023
Summary
This case report details a rare instance of bilateral optic neuropathy, causing vision loss, in a patient with diffuse cutaneous systemic sclerosis and interstitial lung disease.
Area of Science:
- Ophthalmology
- Rheumatology
- Pulmonology
Background:
- Diffuse cutaneous systemic sclerosis (SSc) is a multisystem autoimmune disease.
- Interstitial lung disease (ILD) is a common complication of SSc.
- Optic neuropathy is an uncommon complication of SSc.
Observation:
- A middle-aged female with known diffuse cutaneous SSc and ILD presented with sudden, painless bilateral vision loss.
- Fundoscopy revealed bilateral optic atrophy.
- Serum anti-topoisomerase I antibodies were positive, indicating SSc.
Findings:
- Reduced serum vitamin B12 and folate levels were noted.
- HRCT chest confirmed ILD.
- MRI orbit showed kinking of the left optic nerve, contributing to neuropathy.
Implications:
- This case highlights a rare presentation of bilateral optic neuropathy in SSc-ILD.
- Early recognition and management of visual impairment are crucial in SSc patients.
- Further research may elucidate the pathogenic mechanisms linking SSc, ILD, and optic neuropathy.
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