Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

788
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
788
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

109
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
109
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

135
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
135

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dorsomedial prefrontal cortex links abstract planning to motor execution.

Communications biology·2026
Same author

Electroencephalography Microstate Instability and Clinical Outcomes in Individuals at Clinical High Risk of Psychosis.

JAMA psychiatry·2026
Same author

Biophysical Modeling of Excitation/Inhibition Balance and Conversion to Psychosis in the Clinical High Risk Syndrome.

Biological psychiatry·2026
Same author

Baseline Mismatch Negativity Amplitude Predicts Direction and Magnitude of Ketamine Effect in Healthy Volunteers: A Disordinal Effect.

Biological psychiatry·2026
Same author

Cognition and Electrophysiology Clustering in Clinical High Risk for Psychosis Delineates Distinct Dimensions of Heterogeneity: Implications for Multimodal Clustering.

medRxiv : the preprint server for health sciences·2026
Same author

Visual P300 and Risk for Psychosis Onset in Youth at Clinical High Risk.

Biological psychiatry·2026

Related Experiment Video

Updated: Aug 3, 2025

An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children
05:04

An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children

Published on: October 4, 2018

7.0K

Alpha Event-Related Desynchronization During Reward Processing in Schizophrenia.

Susanna L Fryer1, Tobias F Marton1, Brian J Roach2

  • 1VA San Francisco Healthcare System, Mental Health Service, San Francisco, California; Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California.

Biological Psychiatry. Cognitive Neuroscience and Neuroimaging
|April 12, 2023
PubMed
Summary
This summary is machine-generated.

Individuals with schizophrenia exhibit altered alpha band activity during reward processing. Higher trait rumination is linked to reduced external attention to reward feedback in both healthy individuals and those with schizophrenia.

Keywords:
AmotivationAnhedoniaEEGNeuro-oscillationsReward systemRumination

More Related Videos

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

3.6K
Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

9.0K

Related Experiment Videos

Last Updated: Aug 3, 2025

An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children
05:04

An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children

Published on: October 4, 2018

7.0K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

3.6K
Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

9.0K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Schizophrenia (SZ) is associated with deficits in motivation and pleasure, potentially linked to reward system alterations.
  • Alpha band neuro-oscillations are implicated in directing attention towards external stimuli, including reward feedback.
  • Reduced alpha band event-related desynchronization (ERD) in SZ may indicate less external focus during reward processing.

Purpose of the Study:

  • To investigate alterations in reward-related alpha band event-related desynchronization (ERD) in individuals with schizophrenia.
  • To examine the relationship between alpha ERD, negative symptoms in schizophrenia, and trait rumination across groups.

Main Methods:

  • Electroencephalography (EEG) was used to record brain activity in participants with SZ (n=54) and healthy controls (n=54) during a slot machine task.
  • Alpha band power (8-14 Hz) was analyzed to measure neural oscillation magnitude.
  • Associations between alpha power, reward outcomes, negative symptoms, and trait rumination were statistically evaluated.

Main Results:

  • A significant group by reward outcome interaction revealed that healthy controls showed reduced posterior-occipital alpha power to wins versus losses, unlike individuals with SZ.
  • Alpha ERD during reward processing in SZ was not significantly correlated with negative symptoms.
  • Across all participants, lower alpha ERD during reward feedback was associated with higher trait rumination.

Conclusions:

  • Findings demonstrate altered alpha ERD in schizophrenia during reward outcome processing.
  • Trait rumination is inversely associated with external attention to reward feedback, irrespective of group or reward valence.
  • These results highlight the role of neuro-oscillatory alterations and rumination in reward processing deficits.