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Updated: Aug 3, 2025

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Zebrafish Model of Neuroblastoma Metastasis
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Lipid Metabolic Reprogramming in Embryonal Neoplasms with MYCN Amplification
Jyotirmayee Talapatra1,2, Mamatha M Reddy1,2
1The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Bhubaneswar 751024, India.
Cancers
|April 13, 2023
Summary
Cancer cells alter lipid metabolism for rapid growth and energy. This review explores lipid metabolism in embryonal tumors with MYCN dysregulation, highlighting therapeutic targets.
Area of Science:
- Oncology
- Cancer Metabolism
- Molecular Biology
Background:
- Tumor cells exhibit metabolic reprogramming to support uncontrolled proliferation, energy demands, and biosynthesis.
- Altered lipid metabolism is crucial for cancer cells, providing membrane components, energy, and signaling molecules.
Purpose of the Study:
- To review the role of lipid metabolism in embryonal neoplasms characterized by MYCN dysregulation.
- To discuss potential therapeutic strategies targeting lipid metabolism in these cancers.
Main Methods:
- Literature review focusing on lipid metabolism in specific embryonal tumors.
- Analysis of the regulation of lipid metabolism by the MYCN oncogene.
Main Results:
- Lipid metabolic reprogramming is a hallmark of embryonal neoplasms with MYCN dysregulation.
- Specific lipid metabolic pathways are altered in neuroblastoma, retinoblastoma, medulloblastoma, Wilms tumor, and rhabdomyosarcoma.
Conclusions:
- Targeting lipid metabolism presents a promising therapeutic avenue for embryonal neoplasms with MYCN dysregulation.
- The MYCN oncogene plays a significant role in regulating lipid metabolism in these cancers.
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