Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ZW4864-mediated inhibition of the β-catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer.

Molecular oncology·2026
Same author

Urinary biomarkers in multicentric studies: Shaping the future of bladder cancer diagnosis and follow-up.

BJUI compass·2025
Same author

Notch2/3-DLL4 interaction in urothelial cancer cell lines supports a tumorigenic role of Notch signaling pathways in bladder carcinoma.

PloS one·2025
Same author

Ionizing radiation and photodynamic therapy lead to multimodal tumor cell death, synergistic cytotoxicity and immune cell invasion in human bladder cancer organoids.

Photodiagnosis and photodynamic therapy·2025
Same author

Real-world performance of Uromonitor® in urothelial bladder cancer detection: a multicentric trial.

BJU international·2024
Same author

Cell Line-Based Human Bladder Organoids with Bladder-like Self-Organization-A New Standardized Approach in Bladder Cancer Research.

Biomedicines·2023
Same journal

RETRACTED: Kim et al. The Angiogenesis Inhibitor ALS-L1023 from Lemon-Balm Leaves Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease Through Regulating the Visceral Adipose-Tissue Function. <i>Int. J. Mol. Sci.</i> 2017, <i>18</i>, 846.

International journal of molecular sciences·2026
Same journal

Correction: Mahmud et al. Thymoquinone Attenuates NF-κβ Signalling Activation in Retinal Pigment Epithelium Cells Under AMD-Mimicking Conditions. <i>Int. J. Mol. Sci.</i> 2025, <i>26</i>, 11473.

International journal of molecular sciences·2026
Same journal

Correction: Borovikov et al. The Twisting and Untwisting of Actin and Tropomyosin Filaments Are Involved in the Molecular Mechanisms of Muscle Contraction, and Their Disruption Can Result in Muscle Disorders. <i>Int. J. Mol. Sci</i>. 2025, <i>26</i>, 6705.

International journal of molecular sciences·2026
Same journal

Correction: Molagoda et al. Flavonoid Glycosides from <i>Ziziphus jujuba</i> var. <i>inermis</i> (Bunge) Rehder Seeds Inhibit α-Melanocyte-Stimulating Hormone-Mediated Melanogenesis. <i>Int. J. Mol. Sci.</i> 2021, <i>22</i>, 7701.

International journal of molecular sciences·2026
Same journal

Correction: Guo et al. Integrated Transcriptomic and Metabolomic Analysis Reveals the Molecular Regulatory Mechanism of Flavonoid Biosynthesis in Maize Roots Under Lead Stress. <i>Int. J. Mol. Sci.</i> 2024, <i>25</i>, 6050.

International journal of molecular sciences·2026
Same journal

Correction: Chang et al. Improvement of Carbon Tetrachloride-Induced Acute Hepatic Failure by Transplantation of Induced Pluripotent Stem Cells Without Reprogramming Factor c-Myc. <i>Int. J. Mol. Sci.</i> 2012, <i>13</i>, 3598-3617.

International journal of molecular sciences·2026
See all related articles

Related Experiment Video

Updated: Aug 3, 2025

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
09:28

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

10.2K

3D Tumor Models in Urology.

Jochen Neuhaus1, Anja Rabien2, Annabell Reinhold1

  • 1Department of Urology, Research Laboratory, University Leipzig, D-04103 Leipzig, Germany.

International Journal of Molecular Sciences
|April 13, 2023
PubMed
Summary
This summary is machine-generated.

Three-dimensional tumor models like organoids offer better insights into urologic cancers than 2D cultures. This review explores their application in bladder, prostate, and kidney cancer research.

Keywords:
3D cell culture techniquebladder cancerprostate cancerrenal cell carcinoma

More Related Videos

Multicolor 3D Printing of Complex Intracranial Tumors in Neurosurgery
14:15

Multicolor 3D Printing of Complex Intracranial Tumors in Neurosurgery

Published on: January 11, 2020

7.2K
Establishment and Analysis of Three-Dimensional 3D Organoids Derived from Patient Prostate Cancer Bone Metastasis Specimens and their Xenografts
07:21

Establishment and Analysis of Three-Dimensional 3D Organoids Derived from Patient Prostate Cancer Bone Metastasis Specimens and their Xenografts

Published on: February 3, 2020

9.4K

Related Experiment Videos

Last Updated: Aug 3, 2025

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
09:28

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

10.2K
Multicolor 3D Printing of Complex Intracranial Tumors in Neurosurgery
14:15

Multicolor 3D Printing of Complex Intracranial Tumors in Neurosurgery

Published on: January 11, 2020

7.2K
Establishment and Analysis of Three-Dimensional 3D Organoids Derived from Patient Prostate Cancer Bone Metastasis Specimens and their Xenografts
07:21

Establishment and Analysis of Three-Dimensional 3D Organoids Derived from Patient Prostate Cancer Bone Metastasis Specimens and their Xenografts

Published on: February 3, 2020

9.4K

Area of Science:

  • Oncology
  • Biotechnology
  • Urology

Background:

  • Three-dimensional (3D) tumor models are increasingly used in research.
  • Multicellular 3D models better mimic tumor complexity than 2D cultures.
  • These models are vital for advancing urologic cancer research.

Purpose of the Study:

  • To review the applications of tumor spheroids and organoids in urology.
  • To illustrate the generation and characteristics of 3D models in bladder cancer.
  • To discuss molecular analysis successes in urinary bladder, prostate, and renal cell carcinomas.

Main Methods:

  • Review of current literature on 3D tumor models in urology.
  • Illustration of standardized organoid and membrane-based 3D model generation.
  • Discussion of technical aspects and molecular analyses.

Main Results:

  • 3D models provide superior representation of tumor characteristics.
  • Standardized organoids and 3D in vitro models are being developed for bladder cancer.
  • Initial successes in molecular analyses of bladder, prostate, and renal cell carcinomas are reported.

Conclusions:

  • 3D tumor models hold significant potential for urologic cancer research.
  • Further development and application of these models will enhance understanding and treatment.
  • Molecular analyses in 3D models are crucial for advancing urologic oncology.