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Updated: Aug 3, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
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Roles of p53-Mediated Host-Virus Interaction in Coronavirus Infection

Xue Wang1, Yi Liu1, Kaiyuan Li1

  • 1College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.

International Journal of Molecular Sciences
|April 13, 2023
PubMed

Insights

Coronaviruses, like SARS-CoV-2, challenge drug development due to rapid mutation. Targeting the host cell

Area of Science:

  • Virology
  • Molecular Biology
  • Oncology

Background:

  • SARS-CoV-2 poses significant global health and economic challenges.
  • Existing antivirals face limitations due to coronavirus high mutation rates and proofreading mechanisms.
  • Coronaviruses manipulate host cell processes, including stress responses, cell cycle, apoptosis, and immune function.

Purpose of the Study:

  • To review the complex interactions between p53 and coronaviruses.
  • To explore p53 as a potential therapeutic target for antiviral drug development and vaccine design against coronaviruses.

Main Methods:

  • Comprehensive literature review of studies on coronavirus-host interactions.
  • Analysis of the role of the p53 tumor suppressor in cellular responses to viral infections.
  • Examination of p53's involvement in pathways affected by coronaviruses.

Main Results:

  • Coronaviruses can modulate p53 activity to facilitate viral replication.
  • p53 plays a crucial role in regulating cellular stress, DNA repair, and apoptosis, processes often hijacked by viruses.
  • Understanding p53's dynamic interaction with coronaviruses is key to identifying therapeutic vulnerabilities.

Conclusions:

  • The p53 tumor suppressor is a critical node in the host response to coronavirus infection.
  • Targeting p53 offers a promising strategy for developing novel antiviral therapies and effective vaccine designs.
  • Further research into p53-coronavirus interactions could unlock new avenues for combating viral diseases.
Keywords:
antiviralcoronavirusp53

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