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[Transient hyperphosphatasemia in infants and young children]
Insights
Transient hyperphosphatasemia of infancy involves temporary high serum alkaline phosphatase in infants. This condition resolves within 12 weeks, avoiding unnecessary diagnostic tests.
Area of Science:
- Pediatric Endocrinology
- Clinical Biochemistry
Context:
- Infants aged 6.5 to 30 months presented with elevated serum alkaline phosphatase.
- No clinical signs of hepatic or skeletal disease were observed in affected infants.
Purpose:
- To report new cases of transient hyperphosphatasemia of infancy.
- To emphasize the importance of recognizing this benign condition to prevent unnecessary investigations.
Summary:
- Nine cases of transient hyperphosphatasemia of infancy are detailed, characterized by significant, temporary increases in serum alkaline phosphatase.
- Etiology remains unknown, but levels normalized within 12 weeks in all patients.
- A diagnostic protocol is recommended to identify this condition and avoid costly procedures.
Impact:
- Increased awareness of transient hyperphosphatasemia can prevent misdiagnosis and reduce healthcare costs.
- Facilitates appropriate clinical management by distinguishing it from serious liver or bone disorders.
Abstract:
Transient hyperphosphatasemia of infancy. Striking transient increases in serum alkaline phosphatase in nine new cases are reported. The etiology is still unknown. The patients were 6.5 months to 30 months of age and none showed any clinical evidence of hepatic or skeletal disease. Values became normal within 12 weeks in all patients. It is important to know this condition to avoid unnecessary and expensive diagnostic procedures. Though hyperphosphatasemia does not seem to give any problems we recommend a brief diagnostic protocol in order to recognize transient hyperphosphatasemia of infancy.