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[Transient hyperphosphatasemia in infants and young children]
Tijdschrift Voor Kindergeneeskunde
|February 1, 1986
Summary
Transient hyperphosphatasemia of infancy involves temporary high serum alkaline phosphatase in infants. This condition resolves within 12 weeks, avoiding unnecessary diagnostic tests.
Area of Science:
- Pediatric Endocrinology
- Clinical Biochemistry
Context:
- Infants aged 6.5 to 30 months presented with elevated serum alkaline phosphatase.
- No clinical signs of hepatic or skeletal disease were observed in affected infants.
Purpose:
- To report new cases of transient hyperphosphatasemia of infancy.
- To emphasize the importance of recognizing this benign condition to prevent unnecessary investigations.
Summary:
- Nine cases of transient hyperphosphatasemia of infancy are detailed, characterized by significant, temporary increases in serum alkaline phosphatase.
- Etiology remains unknown, but levels normalized within 12 weeks in all patients.
- A diagnostic protocol is recommended to identify this condition and avoid costly procedures.
Impact:
- Increased awareness of transient hyperphosphatasemia can prevent misdiagnosis and reduce healthcare costs.
- Facilitates appropriate clinical management by distinguishing it from serious liver or bone disorders.