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Mammalian Cell-Growth Monitoring Based on an Impedimetric Sensor and Image Processing within a Microfluidic Platform.

Ivana Podunavac1, Teodora Knežić1, Mila Djisalov1

  • 1BioSense Institute, University of Novi Sad, Dr. Zorana Đinđića 1, Novi Sad 21000, Serbia.

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Summary

This study introduces a microfluidic platform with an integrated impedimetric sensor for precise cell growth monitoring. The system accurately tracks all cell growth phases, aiding bioprocess optimization.

Keywords:
PMMAbiomassimpedimetric sensorinkjet printinginterdigitated electrodesmicrobioreactormicrofluidicsscaled-down

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Area of Science:

  • Biotechnology
  • Microfluidics
  • Sensor Technology

Background:

  • Cell growth monitoring is crucial for bioprocesses.
  • Traditional methods can be complex and time-consuming.
  • Advancements in microfluidics and sensors offer new monitoring solutions.

Purpose of the Study:

  • To propose a microfluidic (MF) platform with a microbioreactor and integrated impedimetric sensor for cell growth monitoring.
  • To demonstrate the platform's utility in a scaled-down simulator for bioprocess optimization, such as cultivated meat production.
  • To enable real-time monitoring and advanced control of cell growth.

Main Methods:

  • Fabrication of a microfluidic platform with an integrated impedimetric sensor using inkjet printing.
  • Design of an interdigitated electrode (IDE) sensor for impedimetric measurements.
  • Integration of the sensor into a custom-made microfluidic platform serving as a scaled-down simulator.
  • Application to MRC-5 cells for monitoring cell growth over a 96-h cultivation period.
  • Combination of impedimetric approach with image processing for real-time biomass monitoring.

Main Results:

  • The impedimetric sensor precisely detected all cell growth phases (lag, exponential, stationary, dying) for MRC-5 cells.
  • The microfluidic system demonstrated effective cell growth monitoring even with limited nutrients.
  • The platform facilitated real-time monitoring of biomass and advanced control of cell growth progress.
  • The simple and rapid fabrication of the MF system makes it suitable for scaled-down analyses.

Conclusions:

  • The proposed microfluidic platform with an integrated impedimetric sensor is an excellent tool for scaled-down cell growth analysis.
  • This technology can be valuable for optimizing bioprocesses, including cultivated meat production.
  • The combined impedimetric and image processing approach enables comprehensive real-time monitoring and control of cell cultivation.