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Dynamically Visualized Mechano-Responsive Supramolecular Self-Assembly System for Small Molecule Release.

Shihong Wu1, Jiajia Qi1, Xin Xia1

  • 1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Med-X Center for Materials, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.

Chemistry (Weinheim an Der Bergstrasse, Germany)
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Summary
This summary is machine-generated.

This study introduces a novel small molecule system for ultrasound-controlled drug delivery, enabling multiple precise releases without complex polymers. This mechano-responsive system offers a new approach for mechanochemistry applications.

Keywords:
dynamic chemical bondmultiple mechano-responsephase transitionsmall molecule releasesupramolecular self-assembly

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Area of Science:

  • Supramolecular Chemistry
  • Mechanochemistry
  • Materials Science

Background:

  • Ultrasound (US)-controlled drug release offers non-invasive, precise delivery.
  • Current small molecule mechano-release systems often rely on complex polymer bases with limited responsiveness.

Purpose of the Study:

  • To develop a novel, small molecule-based mechano-responsive system for controlled drug release.
  • To investigate the mechanism behind multi-responsive release in the developed system.
  • To explore potential applications in ultrasound-triggered drug delivery.

Main Methods:

  • One-pot synthesis of an isoguanosine (isoG) visualized mechano-responsive supramolecular self-assembly (isoG-VMRSS) system.
  • Characterization of the supramolecular network structure using combined experimental and computational approaches.
  • Evaluation of the mechano-responsive release capabilities of the system.

Main Results:

  • Successfully constructed a small molecule-only isoG-VMRSS system via a one-pot reaction.
  • Demonstrated multiple (≥9 times) mechano-responsive releases of isoguanosine.
  • Identified the underlying mechanism involving a supramolecular network formed by metal coordination, boronate ester, and hydrogen bonds.

Conclusions:

  • The developed isoG-VMRSS system provides a versatile platform for small molecule-based mechano-responsive release.
  • This system overcomes limitations of polymer-based approaches, offering simpler preparation and enhanced responsiveness.
  • Presents a novel strategy for ultrasound-controlled drug release and mechanochemistry applications.