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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

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Impact of Mild Behavioral Impairment on Longitudinal Changes in Cognition

Hillary J Rouse1, Zahinoor Ismail2,3, Ross Andel4,5

  • 1School of Aging Studies, University of South Florida, Tampa, Florida, USA.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|April 13, 2023
PubMed
Abstract

Insights

Mild Behavioral Impairment (MBI) is linked to worse cognitive function in older adults, affecting attention, memory, and executive functions. This association holds true for both healthy individuals and those with Mild Cognitive Impairment (MCI).

Area of Science:

  • Neuroscience
  • Gerontology
  • Cognitive Psychology

Background:

  • Mild Behavioral Impairment (MBI) is increasingly recognized as a potential precursor or correlate of cognitive decline.
  • Understanding the relationship between MBI and cognitive performance is crucial for early detection and intervention in aging populations.

Purpose of the Study:

  • To investigate the cross-sectional and longitudinal cognitive performance differences in older adults with and without Mild Behavioral Impairment (MBI).
  • To compare cognitive function between cognitively healthy individuals and those with Mild Cognitive Impairment (MCI), considering the presence or absence of MBI.

Main Methods:

  • Utilized secondary data analysis from the National Alzheimer's Coordinating Center database, including 17,291 participants.
  • Assessed cognitive performance using a comprehensive neuropsychological battery covering attention, episodic memory, executive function, language, visuospatial ability, and processing speed.
  • Categorized participants into cognitively healthy (n=11,771) and Mild Cognitive Impairment (MCI) (n=5,520) groups, with 24.7% meeting MBI criteria.

Main Results:

  • Older adults with MBI showed significantly poorer baseline performance across multiple cognitive domains (attention, episodic memory, executive function, language, processing speed) compared to those without MBI.
  • Individuals with MBI exhibited greater longitudinal cognitive decline in attention, episodic memory, language, and processing speed.
  • Cognitively healthy older adults with MBI performed worse on visuospatial ability and processing speed tasks than healthy controls without MBI.

Conclusions:

  • Mild Behavioral Impairment (MBI) is significantly associated with poorer cross-sectional and longitudinal cognitive performance.
  • The presence of MBI exacerbates cognitive deficits in individuals with Mild Cognitive Impairment (MCI), particularly in executive function and visuospatial abilities.
  • MBI appears to be uniquely associated with various cognitive domains, highlighting its importance in understanding cognitive aging.
Keywords:
Alzheimer’s diseaseCognitionDementiaLongitudinal changesMild behavioral impairment

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