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Microbiome of the Eye

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The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...

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Updated: Jun 30, 2026

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

EBD: an eye biomarker database.

Xueli Zhang^1,2, Lingcong Kong³, Shunming Liu¹

¹Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, No. 106 Zhongshan Second Road, Guangzhou 510080, China.

Bioinformatics (Oxford, England)

|April 13, 2023

Summary

This summary is machine-generated.

The Eye Biomarker Database (EBD) compiles 889 ocular and 939 systemic disease biomarkers. This resource aids researchers and clinicians in identifying eye-related biomarkers for improved disease diagnosis and management.

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Biobanking of Human Aqueous and Vitreous Liquid Biopsies for Molecular Analyses

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Area of Science:

Ophthalmology
Biomarker Discovery
Bioinformatics

Background:

Ophthalmic diseases and systemic conditions can be diagnosed and managed using biomarkers.
The eye itself can serve as a biomarker for systemic diseases.
Comprehensive multiomics profiling has identified numerous potential ophthalmic disease biomarkers.

Purpose of the Study:

To create a centralized, standardized online repository of eye biomarker information.
To develop the Eye Biomarker Database (EBD) for ophthalmologists and researchers.
To facilitate the search, analysis, and download of eye biomarker data.

Main Methods:

Collected and standardized data on eye biomarkers for ocular and systemic diseases.
Constructed the Eye Biomarker Database (EBD) as an online platform.
Performed biological function and network analysis on ocular disease biomarkers.

Main Results:

The EBD contains 889 biomarkers for 26 ocular diseases and 939 for 181 systemic diseases.
Identified novel hub pathways and network characteristics for ocular disease biomarkers.
Included 78 "nonbiomarkers" to refine biomarker identification.

Conclusions:

The EBD is a valuable resource for identifying biomarkers linked to eye disorders and related systemic diseases.
Network analysis provides insights into the landscape of biomarkers for eye diseases.
The EBD is expected to benefit developmental biologists and clinical scientists in and outside the ophthalmology field.