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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Innate Immunity System in Patients With Cardiovascular and Kidney Disease

Carmine Zoccali1, Francesca Mallamaci2

  • 1Renal Research Institute New York and Institute of Molecular Biology and genetics (BIOGEM), Ariano Irpino, Italy and Associazione Ipertensione, Nefrologia, Trapianto (IPNET), Reggio Calabria Italy (C.Z.).

Circulation Research
|April 13, 2023
PubMed

Insights

Chronic kidney disease (CKD) patients face high cardiovascular risk due to systemic inflammation. Targeting inflammation pathways shows promise for improving both kidney and heart health outcomes in CKD.

Area of Science:

  • Nephrology
  • Immunology
  • Cardiology

Background:

  • Chronic kidney disease (CKD) affects 844 million globally, posing a significant public health challenge.
  • Systemic inflammation is a key driver of cardiovascular complications in CKD patients.
  • Multiple factors contribute to severe inflammation in CKD, including cellular senescence and immune activation.

Purpose of the Study:

  • To explore the role of systemic inflammation in CKD progression and cardiovascular events.
  • To evaluate the potential of targeting innate immune responses for improved patient outcomes.
  • To review existing and emerging therapies aimed at mitigating inflammation in CKD.

Main Methods:

  • Analysis of cohort studies linking inflammation biomarkers to CKD progression and cardiovascular events.
  • Review of clinical trial data for anti-inflammatory agents in cardiovascular and kidney disease.
  • Examination of mechanisms driving inflammation in CKD, such as cellular senescence and immune activation.

Main Results:

  • Inflammation biomarkers are strongly associated with increased risk of kidney failure and cardiovascular events in CKD.
  • Inhibition of interleukin-1 beta (IL-1β) signaling reduced cardiovascular events in patients with coronary heart disease, including those with CKD.
  • Ongoing trials are investigating drugs like ziltivekimab (IL-6 antagonist) for CKD and cardiovascular benefits.

Conclusions:

  • Mitigating systemic inflammation is a promising therapeutic strategy for reducing cardiovascular and kidney disease risks in CKD patients.
  • Targeting innate immune pathways offers a potential avenue for novel treatments.
  • Further research and clinical trials are crucial to validate these anti-inflammatory approaches.

Keywords:
cardiovascular riskdialysisimmunity, innateinflammationinterleukins

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