Related Experiment Video
Updated: Aug 2, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Smoking-Related Interstitial Lung Diseases.
Amarilys Alarcon-Calderon1, Robert Vassallo1, Eunhee S Yi2
1Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, 200 1st Street, Southwest, Rochester, MN 55905, USA.
This review covers smoking-related interstitial lung diseases (ILDs), including their causes, symptoms, diagnosis, and treatments. It also addresses incidental findings like interstitial lung abnormalities and smoking-related fibrosis.
Area of Science:
- Pulmonology
- Toxicology
- Radiology
Background:
- Smoking is a major cause of diffuse lung diseases.
- Interstitial lung diseases (ILDs) are a diverse group of lung conditions linked to tobacco use.
- These include conditions like pulmonary Langerhans cell histiocytosis and desquamative interstitial pneumonia.
Purpose of the Study:
- To review the current understanding of smoking-related interstitial lung diseases (ILDs).
- To summarize evidence on pathogenesis, clinical features, diagnosis, prognosis, and treatment.
- To discuss incidentally detected interstitial lung abnormalities and smoking-related fibrosis.
Main Methods:
- Comprehensive literature review of smoking-related ILDs.
- Analysis of current evidence on disease mechanisms and clinical presentation.
- Evaluation of diagnostic strategies and therapeutic options.
Main Results:
- Smoking-related ILDs are a heterogeneous group of lung diseases.
- Key conditions include pulmonary Langerhans cell histiocytosis, respiratory bronchiolitis-associated ILD, and others.
- Radiologic and biopsy findings, including incidental abnormalities, are discussed.
Conclusions:
- Understanding the pathogenesis and clinical spectrum of smoking-related ILDs is crucial.
- Early diagnosis and appropriate management can improve patient outcomes.
- Further research into interstitial lung abnormalities and smoking-related fibrosis is warranted.
Related Concept Videos
Other Pulmonary Disorders
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Chronic Obstructive Pulmonary Disease-I: Introduction
Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...

