Related Experiment Video
Updated: Aug 2, 2025
Methodology for Sputum Induction and Laboratory Processing
Published on: December 17, 2017
THE INFLUENCE OF SPELEOTHERAPY ON BRONCHI PASSAGE IN CHILDREN WITH BRONCHIAL ASTHMA USING A PHARMACO-FUNCTIONAL TEST
Volodymyr M Bilak1, Lyudmila V Ignatko1, Natalya V Sochka1
1STATE HIGHER EDUCATIONAL ESTABLISHMENT «UZHHOROD NATIONAL UNIVERSITY», UZHHOROD, UKRAINE.
Insights
Speleotherapy improved bronchial asthma symptoms in children. It normalized bronchial tone and improved airway function in response to salbutamol (a bronchodilator) for those with intermittent and mild asthma.
Area of Science:
- Pediatric Pulmonology
- Environmental Medicine
- Respiratory Physiology
Background:
- Bronchial asthma is a chronic respiratory condition affecting children.
- Asthma severity varies, impacting bronchial tone and patency.
- Speleotherapy, a natural cave environment treatment, is explored for its therapeutic effects.
Purpose of the Study:
- To evaluate the effect of speleotherapy on bronchial reactivity to salbutamol in children with different asthma severities.
- To assess changes in bronchial tone and patency following speleotherapy.
Main Methods:
- A study involving 40 children (6-15 years) with intermittent or mild asthma.
- Pharmaco-functional testing (PFT) with salbutamol was used to assess external respiration function (FER).
- Measurements were taken before and after speleotherapy, with comparisons to 40 healthy children.
Main Results:
- Speleotherapy led to decreased bronchial tone and restored patency in all children with intermittent asthma.
- Children with mild asthma showed a partial decrease in bronchial hyperreactivity and improved patency.
- Positive bronchodilator response to salbutamol was observed post-speleotherapy.
Conclusions:
- Speleotherapy positively influences bronchial response to salbutamol in pediatric asthma.
- The treatment normalizes bronchial tone and restores patency, particularly in intermittent and mild asthma cases.
- Speleotherapy offers a potential complementary therapy for managing childhood asthma.
Objective:
The aim: To investigate the reaction of the bronchi to inhalation of salbutamol in children with different severity of bronchial asthma under the conditions of speleotherapy.
Patients And Methods:
Materials and methods: 40 children aged 6-15 years were examined, 20 of them had an intermittent course of the disease, 20 had a mild course, and the children were in the inter-relapse period. Determining the function of external respiration (FER) with a pharmaco-functional test (PFT) with salbutamol was carried out in the dynamics of observation before and after treatment and compared with the indicators of 40 healthy children. Speleotherapy was performed based on the children's department of the Ukrainian Allergological Hospital of the village Solotvino.
Results:
Results: A decrease in increased bronchial tone and restoration of bronchial patency at all levels of the bronchi in all patients with an intermittent course of the disease and a partial decrease in bronchial hyperreactivity with the improvement of bronchial patency in children with a mild course of bronchial asthma under the influence of speleotherapy was established.
Conclusion:
Conclusions: Thus, speleotherapy contributes to a positive reaction of the bronchi to inhalation of salbutamol, which is reflected in the normalization of disturbed bronchial tone and the restoration of bronchial patency at all levels of the bronchi, in all patients with an intermittent course and partially with a mild course of the disease.
Related Concept Videos
01:25Antiasthma Drugs: β2-Adrenoceptor Agonists
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
01:30Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
01:24Antiasthma Drugs: Methylxanthines
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
01:17Drugs Used in Lower Respiratory Disorders: Overview
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
01:20Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:23Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...