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Updated: Aug 2, 2025
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Single Atom-Engineered NIR-II Gold Clusters with Ultrahigh Brightness and Stability for Acute Kidney Injury
You Huang1, Ke Chen1, Ling Liu1
1Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China.
Small (Weinheim an Der Bergstrasse, Germany)
|April 14, 2023
Summary
Atom-engineered gold clusters offer ultrahigh brightness and stability for near-infrared-II imaging. These novel agents enable long-term monitoring of acute kidney injury progression and possess therapeutic potential.
Area of Science:
- Nanotechnology
- Biomedical Imaging
- Materials Science
Background:
- Near-infrared-II (NIR-II) imaging is crucial for deep tissue visualization and disease monitoring.
- Current NIR-II agents lack sufficient brightness and photostability for real-time applications.
- Developing advanced NIR-II agents is essential for clinical translation.
Purpose of the Study:
- To develop novel atom-engineered gold clusters for enhanced NIR-II imaging.
- To investigate the impact of single atomic doping on cluster properties.
- To evaluate the potential of these clusters in monitoring kidney injury and inflammation.
Main Methods:
- Synthesis of NIR-II Au24Cd1 clusters via single atomic cadmium doping.
- Characterization of fluorescence enhancement, stability, and photostability.
- In vivo imaging of acute kidney injury (AKI) progression in animal models.
- Assessment of the therapeutic effects on oxidative stress and neuroinflammation.
Main Results:
- Au24Cd1 clusters exhibited a 56-fold fluorescence enhancement compared to undoped clusters.
- Achieved exceptional stability for up to 1 month and photostability for 1 hour, surpassing indocyanine green.
- Successfully monitored AKI progression for over 72 hours post-injury.
- Demonstrated alleviation of AKI-induced oxidative stress and neuroinflammation.
Conclusions:
- Single atom doping significantly enhances the performance of gold clusters for NIR-II imaging.
- Atom-engineered gold clusters provide a robust platform for long-term disease monitoring.
- These bioactive clusters show promise for both diagnostic and therapeutic applications in kidney diseases.
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