Related Experiment Video
Updated: Aug 2, 2025
08:00
The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Published on: April 16, 2019
18.2K
TIL Therapy: Facts and Hopes
Tine J Monberg1, Troels H Borch1, Inge M Svane1
1Department of Oncology, National Center for Cancer Immune Therapy (CCIT-DK), Copenhagen University Hospital, Herlev and Gentofte, Herlev, Denmark.
Summary
Tumor-infiltrating lymphocytes (TIL) therapy shows promise for metastatic melanoma and other solid tumors. Overcoming regulatory and logistical hurdles is key to expanding access to this effective treatment.
Area of Science:
- Immunotherapy
- Oncology
- Cellular Therapy
Background:
- Tumor-infiltrating lymphocytes (TIL) therapy has demonstrated safety, feasibility, and efficacy in Phase III trials for metastatic melanoma.
- The treatment's applicability extends to diverse solid tumors, irrespective of histologic type.
- Despite positive trial outcomes, TIL therapy lacks widespread regulatory approval, limiting its availability to specialized centers.
Approach:
- This review synthesizes current knowledge on TIL therapy.
- It examines the practical, logistical, and economic challenges hindering large-scale implementation.
- Strategies for facilitating broader adoption and developing next-generation TILs are proposed.
Key Points:
- TIL therapy is a proven, safe, and effective treatment for metastatic melanoma.
- Feasibility is demonstrated across various solid tumor types.
- Regulatory and logistical barriers impede widespread clinical use.
Conclusions:
- Widespread implementation of TIL therapy requires addressing practical, logistical, and economic challenges.
- Developing next-generation TILs is crucial for advancing the field.
- Facilitating broader access to TIL therapy will improve patient outcomes in oncology.
Related Concept Videos
02:49Cancer Therapies
7.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.8K
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
00:59Gene Therapy
25.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
25.6K
01:29Microorganisms in Medicine and Therapeutics
93
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
93
02:56Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
01:26Psychosis: Goals of Pharmacotherapy
173
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
173